Chronicles the lives of a group of midwives living in East London in the late-1950s to mid-1960s.
The original cast consisted of Jessica Raine, Jenny Agutter, Pam Ferris, Miranda Hart, Judy Parfitt, Helen George, Bryony Hannah, Laura Main, Cliff Parisi and Stephen McGann. Agutter, George, Main, Parisi and McGann are the remaining cast members from the first episode.